Ying-Jhen Huang
National Cheng Kung University, Taiwan
Title: Novel wound dressings containing magnesium Ions
Biography
Biography: Ying-Jhen Huang
Abstract
Care for chronic wounds caused by diabetes and pressure sores is still an important clinical problem. A new stratagem to develop innovative wound dressings is needed. During wound healing, magnesium, zinc, copper, and iron are found to be indispensable elements in wound healing, and magnesium ions are the only one involved in all three stages of wound healing [1]. So far, no research has applied magnesium ions in active wound dressings. This study investigates the potential benefit of a novel Mg ions coating nonwoven PP dressing in wound healing in vitro and in vivo rat model.
The morphology of PP dressing after plasma Mg ions coating at 100 nm in thickness did not found any change by SEM, but the contact angle decreased significantly indicated the hydrophilicity alternation. The immersion test by ICP-MS showed the Mg ions almost completely released in 2 days. In vitro test, the Mg ions solution released from the dressing did not show any toxicity effect compared to positive control. In vivo test, twenty adult male Wistar rats was divided into acute (rat model) and the chronic wound (diabetic rat model) groups. The four 1 cm in diameter full-thickness wound were cut on the back (2 on each side) and covered with Mg ions coating dressing or non-coating dressings. The wound area in Mg ions dressing group shows much faster close pace than the control group (without Mg ions coated wound dressing). From temporal histology results also shows epithelialization ability of the Mg ions dressing group has better performance than the control group. Also, the arrangement of cells and extracellular matrix in histology images also show closer to those of intact skin. In conclusion, Mg ions coated PP nonwoven dressing can significantly improve the process of wound healing on acute and chronic wound. It expected to be a new generation of advanced wound dressings.