Ming Jian
Secondary school of Nankai, China
Title: Bio-osteochondral scaffold stress distribution analysis through finite element method for in vivo test
Biography
Biography: Ming Jian
Abstract
Statement of the Problem: Osteoarthritis (OA) is a disease that occurs commonly among the elder people with adverse impact on their life. However, current treatments depending on replacement of joints and operation will cause the osteochondral defect. Osteochondral scaffold, as regenerative medicine could prevent patients from further deterioration of OA. The various pore sizes influence the growth of the cells, their differentiation and relocation.
Nevertheless, balancing them with the ability of mechanical support also need to be considered. Finite element analysis is used to discover the different functions applied to the osteochondral scaffolds with various pore sizes. Methodology & Theoretical Orientation: Scaffolds are 3-D printed by EOS 290 made of titanium alloy-Ti6Al4V. They are cross-link designed, accumulated by the 0.5 minimum-beam. And the interval of columns is 1 minimum. The scaffolds were put into bull’s knee condyle and all sheep were anesthetic by intravenous injection after 3 months. Bone ingrowth were analyzed through CT and micro CT scanning. Scaffolds mechanical properties were analyzed through the finite element analysis under different situation. It resulted in the changes of stress distribution and deformation applied to the scaffolds.
Findings: According to in vivo tests, we found that tissues prefer to regenerate on the scaffold surface. Stress concentration point showed less tissue than the other parts of the scaffolds.
Conclusion & Significance: As for tissue regeneration, tissue could not regenerate well on the scaffold stress concentration area. And 3D printed titanium alloy scaffold showed good bio-performance.